Join the Team!
1. Postdoctoral Position in Cancer/Chemical Biology
Job Summary: A new NIH-funded position is available for postdoctoral candidates with experience in conducting drug screening assays, molecular pharmacology experiments, and in vivo pharmacology studies. The chosen candidate’s work will identify chemical compounds with desirable biological activity profiles that are suitable for escalation within the drug development process. The research fellow is expected to work independently on assigned projects and contribute substantially or wholly to their conception, experimental designs, data generation and analysis, and presentation. The postdoctoral fellow’s research will yield reproducible findings pertaining to the biological actions of drug-like molecules and communicate such findings in scientific publications, patent filings, and grant submissions under the guidance of the PI.
Qualifications, Responsibilities and Skills:
- A doctoral degree or equivalent (Ph.D., M.D., ScD., D.V.M., DDS etc) in an appropriate field.
- Experience with cell culture techniques, molecular biology techniques (FP, ELISA, FRET, BRET, gel electrophoresis, enzyme inhibition assays), biophysical techniques (SPR, ITC), tumor xenograft models, and genetically modified mouse models.
- Preference is shown for candidates with a strong track record in cancer drug discovery/translational research. Previous experience with experimental techniques for the characterization of PROTACs is an additional plus.
- Experience with target deconvolution using molecular pharmacology & biophysical techniques.
- Experience in conducting combination drug studies in cellulo and in vivo for evaluating synergy and antagonism.
- Demonstrable experience with spheroid (3D) viability assays or other in vitro assays that mimic the human tumor microenvironment (e.g. immune cell-based functional assays) is preferred.
- Experience with nucleic acid techniques such as PCR, ChIP-seq, RNAseq, Sanger Sequencing, and next-generation sequencing techniques is a plus.
- Ability to generate stably transfected cell lines for use in high-throughput drug screening assays is preferred.Demonstrated ability to effectively interact and communicate in multidisciplinary project teams, including strong verbal, written communication, and presentation skills.
Excellent organization and planning skills, the ability to work in a fast-paced environment independently and as part of a team, and strong motivation with a dedicated work ethic.
Interested applicants should submit a cover letter indicating availability, CV, statement of research interests, and contact information for three references electronically to Dr. Navnath Gavande at ngavande@wayne.edu. Review of applications will begin immediately and continue until the position is filled.
2. Postdoctoral Position in Medicinal/Organic Chemistry: Cancer Drug Discovery
Job Summary: A postdoctoral position is available in the Department of Pharmaceutical Sciences at the Wayne State University College of Pharmacy and Health Sciences (Eugene Applebaum College of Pharmacy and Health Sciences) to develop small molecule inhibitors for targeted therapies and utilize novel synthetic nanotechnologies or immunotherapy for the treatment of cancer. We are seeking a highly motivated synthetic organic/medicinal chemist to join our comprehensive drug discovery program. We are conducting highly interdisciplinary research focused on the preclinical development of novel anticancer drugs, which covers medicinal chemistry, biochemical and biophysical assays, biological and animal studies.
Qualifications, Responsibilities and Skills:
- Applicant must have a PhD in total synthesis/synthetic organic or medicinal chemistry. This position requires extensive experience in designing synthetic routes for new classes of compounds, solving challenging synthetic problems and comprehensive SAR analysis. Applicant needs expertise in using HPLC, NMR, and MS for organic chemistry applications. Experience in running biological screening assays is desirable, or at least a strong motivation to learn these assay techniques. The ideal candidate will be able to manage multiple projects, balance both chemistry, and biological techniques, and keep pace in a dynamic research environment.
- The successful candidate will carry out research on projects centered around the discovery and development of new anti-cancer agents. The duties will include the design and multi-step organic synthesis of new analogues of existing leads to develop biologically active compounds for testing in cancer cells and animals. The candidate will also assist in carrying out biochemical and cellular assays to evaluate new molecules.
Interested applicants should submit a cover letter indicating availability, CV, statement of research interests, and contact information for three references electronically to Dr. Navnath Gavande at ngavande@wayne.edu. Review of applications will begin immediately and continue until the position is filled.